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Invitrogen
DLX5 Polyclonal Antibody
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DLX5 Antibody (PA5-101134) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded DLX5 in mouse heart tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with DLX5 polyclonal antibody (Product # PA5-101134) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-101134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DLX5(Accession P56178), corresponding to amino acid residues G106-F156.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850578
Product Specific Information
Antibody detects endogenous levels of total DLX5.
Target Information
This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: distal-less homeo box 5; DLX-3; Homeobox protein DLX-3; Homeobox protein DLX-5; RDLX; split hand/foot malformation type 1 with sensorineural hearing loss
Gene Aliases: AI385752; DLX5; RDLX; SHFM1D
UniProt ID: (Human) P56178, (Rat) P50575, (Mouse) P70396
Entrez Gene ID: (Human) 1749, (Rat) 25431, (Mouse) 13395
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
HMG box domain binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
skeletal system development
osteoblast differentiation
endochondral ossification
transcription from RNA polymerase II promoter
nervous system development
axon guidance
cell proliferation
embryonic limb morphogenesis
BMP signaling pathway
epithelial cell differentiation
inner ear morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
palate development
olfactory pit development
face morphogenesis
cellular response to BMP stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription, DNA-templated
regulation of transcription, DNA-templated
axonogenesis
ear development
positive regulation of transcription from RNA polymerase II promoter
head development
bone morphogenesis
ossification
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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