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Bioss
DMO/Dmrt1a Polyclonal Antibody
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DMO/Dmrt1a Antibody (BS-11276R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human prostate tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-DMA/Dmrt1a Polyclonal Antibody, Unconjugated (bs-11276R) at 1:500 overnight at 4°C, followed by a conjugated second... View More
Product Details
BS-11276R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Dmrt1a, amino acids 51-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DM domain expressed in testis 1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
Gene Aliases: CT154; DMRT1; DMT1
UniProt ID: (Human) Q9Y5R6, (Mouse) Q9QZ59
Entrez Gene ID: (Sheep) 101110028, (Human) 1761, (Mouse) 50796, (Rat) 114498
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
DNA binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
male germ cell proliferation
transcription from RNA polymerase II promoter
spermatogenesis
sex differentiation
germ cell migration
male sex determination
intracellular signal transduction
negative regulation of meiotic nuclear division
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
male sex differentiation
oocyte development
Sertoli cell differentiation
Sertoli cell development
positive regulation of meiosis I
regulation of nodal signaling pathway
positive regulation of male gonad development
developmental process involved in reproduction
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
male gonad development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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