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Abnova
DMPK Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 4
DMPK Antibody (H00001760-D01P) in WB
Western Blot analysis of DMPK expression in transfected 293T cell line (H00001760-T01) by DMPK MaxPab polyclonal antibody.
Lane 1: DMPK transfected lysate(69.40 KDa).
Lane 2: Non-transfected lysate.
Lane 1: DMPK transfected lysate(69.40 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00001760-D01P
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DMPK (NP_004400.4, 1 a.a. approximately 629 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR AAALGCIGLV AHAGQLTAVW RRPGAARAP
Target Information
DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DM protein kinase; DM-kinase; DM1 protein kinase; DMK; DMPK; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; MDPK; MT-PK; myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; myotonin protein kinase A; Myotonin-protein kinase; thymopoietin homolog
Gene Aliases: DM; DM1; Dm15; DM1PK; DMK; DMPK; MDPK; MT-PK
UniProt ID: (Human) Q09013, (Mouse) P54265
Entrez Gene ID: (Human) 1760, (Rat) 308405, (Mouse) 13400
protein serine/threonine kinase activity
protein binding
ATP binding
myosin phosphatase regulator activity
heat shock protein binding
metal ion binding
molecular_function
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
regulation of sodium ion transport
protein phosphorylation
cellular calcium ion homeostasis
nuclear envelope organization
regulation of heart contraction
biological_process
muscle cell apoptotic process
regulation of myotube differentiation
regulation of skeletal muscle contraction by calcium ion signaling
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
regulation of catalytic activity
regulation of synapse structural plasticity
peptidyl-serine phosphorylation
regulation of cardiac conduction
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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