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Invitrogen
DMPK Polyclonal Antibody
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Product Details
PA5-52393
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DMPK. Recombinant protein control fragment (Product #RP-89749).
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2640631
Product Specific Information
Immunogen sequence: SDIREGAPLG VHLPFVGYSY SCMALRDSEV PGPTPMELEA EQLLEPHVQA PSLEPSVSPQ DETAEVAVPA AVPAAEAEAE VTLRELQEAL EEEVLTRQSL SREMEAIRTD NQNFASQLRE AEARNRDLEA HVRQLQERME
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 74%.
Target Information
DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DM protein kinase; DM-kinase; DM1 protein kinase; DMK; DMPK; dystrophia myotonica-protein kinase; MT-PK; myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; myotonin protein kinase A; Myotonin-protein kinase; thymopoietin homolog
Gene Aliases: DM; DM1; DM1PK; DMK; DMPK; MDPK; MT-PK
UniProt ID: (Human) Q09013
Entrez Gene ID: (Human) 1760
regulation of sodium ion transport
protein phosphorylation
cellular calcium ion homeostasis
nuclear envelope organization
regulation of heart contraction
muscle cell apoptotic process
regulation of myotube differentiation
regulation of skeletal muscle contraction by calcium ion signaling
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
peptidyl-serine phosphorylation
regulation of catalytic activity
regulation of synapse structural plasticity
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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