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NeoBiotechnologies
DMRT2 (Transcription Factor) Monoclonal Antibody (PCRP-DMRT2-1B11)
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Product Details
10655-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
PCRP-DMRT2-1B11
Immunogen
Recombinant full-length human DMRT2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: HeLa or MCF-7 cells. Cellular Localization: Nucleus
Specificity Comments: The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).
Target Information
Gonadal dysgenesis in 9p-deleted individuals might be due to combined hemizygosity of DMRT1 and DMRT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Doublesex- and mab-3-related transcription factor 2; Doublesex-like 2 protein; doublesex-like 2 protein (DSXL-2); DSXL-2; terra like protein antibody; terra-like protein
Gene Aliases: DMRT2; DSXL2
UniProt ID: (Human) Q9Y5R5
Entrez Gene ID: (Human) 10655
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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