Invitrogen

DNA2 Polyclonal Antibody

5 Published Figures

5 References

View all (9) DNA2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Published Figures (5)

FIGURE: 1 / 5

DNA2 Antibody (PA5-68167) in WB

Cancer research communications 2023 - FIGURE 3 d16 displays on-target effects on DNA2 in mutp53-harboring breast and ovarian cancer cells. Cpd d16 modestly induces apoptosis in MDA-MB-468 ( A ) and MDAH-2774 cells ( B ). Cells were treated with DMSO vehicle or d16 (5 or 10 umol/L) for 21 hours. Active caspase-3/7 was determined by Caspase-Glo 3/7 Assay, and was normalized to protein concentrations. The data shown represent the mean +- SD in MDA... View More

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Product Details

PA5-68167

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human DNA2.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2691658

Product Specific Information

Predicted to react with Mouse samples.

Target Information

DNA2 is a conserved helicase/nuclease involved in themaintenance of mitochondrial and nuclear DNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors.

Cancer research communications

Folly-Kossi H,Graves JD,Garan LAW,Lin FT,Lin WC

Published figure using DNA2 polyclonal antibody (Product # PA5-68167) in Western Blot

Mon Oct 16 00:00:00 UTC 2023

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury.

Frontiers in neuroscience

Leung E,Taskina D,Schwab N,Hazrati LN

PA5-68167 was used in Western Blotting to examine the effects of impaired BRCA1-related repair on DNA damage-induced senescence and outcomes 1-week post-rmTBI using mice with a heterozygous knockout for BRCA1 in a sex-segregated manner.

Tue Aug 29 00:00:00 UTC 2023

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury.

Frontiers in neuroscience

Leung E,Taskina D,Schwab N,Hazrati LN

Tue Aug 29 00:00:00 UTC 2023

Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner.

Frontiers in neuroscience

Schwab N,Taskina D,Leung E,Innes BT,Bader GD,Hazrati LN

PA5-68167 was used in Western Blotting to provide compelling evidence that senescence contributes to brain dysfunction after rmTBI, but may do so in a sex-dependent manner.

Tue Nov 22 00:00:00 UTC 2022

A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.

Nature communications

Griffin WC,McKinzey DR,Klinzing KN,Baratam R,Eliyapura A,Trakselis MA

PA5-68167 was used in Western Blotting to define multifunctional roles for MCM8/9 in promoting normal replication fork progression and genome integrity following stress.

Tue Aug 30 00:00:00 UTC 2022

Early onset senescence and cognitive impairment in a murine model of repeated mTBI.

Acta neuropathologica communications

Schwab N,Ju Y,Hazrati LN

PA5-68167 was used in Western Blotting to identified DNA damage-induced cellular senescence as a repercussion of repeated mild traumatic brain injury which correlates with cognitive impairment.

Sat May 08 00:00:00 UTC 2021

Early onset senescence and cognitive impairment in a murine model of repeated mTBI.

Acta neuropathologica communications

Schwab N,Ju Y,Hazrati LN

PA5-68167 was used in Western Blotting to identified DNA damage-induced cellular senescence as a repercussion of repeated mild traumatic brain injury which correlates with cognitive impairment.

Sat May 08 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2-like helicase; hDNA2

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Gene Aliases: DNA2; DNA2L; E130315B21Rik; hDNA2; KIAA0083

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UniProt ID: (Human) P51530, (Mouse) Q6ZQJ5

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Entrez Gene ID: (Human) 1763, (Mouse) 327762

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Function(s)

DNA binding DNA helicase activity helicase activity nuclease activity protein binding ATP binding ATPase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity 5'-3' DNA helicase activity single-stranded DNA-dependent ATPase activity metal ion binding 4 iron, 4 sulfur cluster binding nucleotide binding catalytic activity endonuclease activity hydrolase activity phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity iron-sulfur cluster binding

Process(es)

DNA replication checkpoint DNA double-strand break processing DNA replication mitochondrial DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus metabolic process DNA duplex unwinding DNA replication, Okazaki fragment processing DNA replication, removal of RNA primer mitochondrial DNA repair positive regulation of DNA replication nucleic acid phosphodiester bond hydrolysis telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair strand displacement regulation of signal transduction by p53 class mediator mitotic telomere maintenance via semi-conservative replication

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DNA2 Polyclonal Antibody

DNA2 Antibody (PA5-68167) in WB

Product Details

PA5-68167

Western Blot (WB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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