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The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
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Protein Aliases: Axonemal dynein intermediate chain 1; Axonemal dynein intermediate chain 2; Dynein axonemal intermediate chain 1; Dynein axonemal intermediate chain 2; dynein intermediate chain 1, axonemal; dynein intermediate chain 2, axonemal; dynein, axonemal, intermediate chain 1; dynein, axonemal, intermediate chain 2; dynein, axonemal, intermediate polypeptide 1; dynein, axonemal, intermediate polypeptide 2; immotile cilia syndrome 1; testis tissue sperm-binding protein Li 87P
Gene Aliases: 1110066F04Rik; b2b1526Clo; BB124644; C030015H18Rik; CILD1; CILD9; DIC1; DIC2; DNAI1; DNAI2; Dnaic1; Dnaic2; Gm728; ICS1; PCD
UniProt ID: (Human) Q9UI46, (Human) Q9GZS0, (Rat) Q5XIL8, (Rat) Q66HC9, (Mouse) Q8C0M8, (Mouse) A2AC93
Entrez Gene ID: (Human) 27019, (Human) 64446, (Rat) 500442, (Rat) 360654, (Mouse) 68922, (Mouse) 432611
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