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Immunogen sequence: VGYGSYDFM KQSRGMLLLY SLKNPSFPEY MFSSNSGVMC LDIHVDHPYL VAVGHYDGNV AIYNLKKPHS QPSFCSSAKS GKHSDPVWQV KWQKDDMDQN LNFFSVSSDG RIVSWTLVKR KLVHIDVIKL KVEGSTTEVP EGLQLHQVGC GTAFDFHKEI DYMFLVGTEE GKIYKCSKSY SSQFLDTYDA HNMSVDTVSW NPYHTKVFMS CSSDWTVKIW DHTIKTPMFI YDLNSAVGDV AWAPYSSTVF AAVTTDGKAH IFDLAINKYE AICNQPVAAK KNRLTHVQFN LIHPIIIVGD DRGHIISLKL SPNLRKMPKE KKGQEVQKGP AVEIAKLDKL LNLVREVKIK T (350-699 aa encoded by BC030583)
Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These protein "motors" contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kDa), three intermediate chains (70-125 kDa), and at least four light chains (15-25 kDa).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Axonemal dynein intermediate chain 1; Dynein axonemal intermediate chain 1; dynein intermediate chain 1, axonemal; dynein, axonemal, intermediate chain 1; dynein, axonemal, intermediate polypeptide 1; ICS; immotile cilia syndrome 1; MGC26204; RP11-296L22.2; testis tissue sperm-binding protein Li 87P
Gene Aliases: CILD1; DIC1; DNAI1; Dnaic1; ICS1; PCD
UniProt ID: (Human) Q9UI46, (Rat) Q5XIL8
Entrez Gene ID: (Human) 27019, (Rat) 500442
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