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DNAJA1 Polyclonal Antibody

DNAJA1 Antibody in Immunocytochemistry (ICC/IF)

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DNAJA1 Antibody (11713-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 11713-1-AP (DNAJA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

DNAJA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11713-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DNAJA1 Fusion Protein Ag2284 (1-397 aa encoded by BC008182)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVKETTYYD VLGVKPNATQ EELKKAYRKL ALKYHPDKNP NEGEKFKQIS QAYEVLSDAK KRELYDKGGE QAIKEGGAGG GFGSPMDIFD MFFGGGGRMQ RERRGKNVVH QLSVTLEDLY NGATRKLALQ KNVICDKCEG RGGKKGAVEC CPNCRGTGMQ IRIHQIGPGM VQQIQSVCME CQGHGERISP KDRCKSCNGR KIVREKKILE VHIDKGMKDG QKITFHGEGD QEPGLEPGDI IIVLDQKDHA VFTRRGEDLF MCMDIQLVEA LCGFQKPIST LDNRTIVITS HPGQIVKHGD IKCVLNEGMP IYRRPYEKGR LIIEFKVNFP ENGFLSPDKL SLLEKLLPER KEVEETDEMD QVELVDFDPN QERRRHYNGE AYEDDEHHPR GGVQCQTS (1-397 aa encoded by BC008182)

Target Information

The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1. 6 kb and a protein product with a molecular weight of about 35 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.

FEBS open bio

Suzuki M,Yamamoto Y,Nishijima-Matsunobu A,Kawasaki Y,Shibata H,Omori Y

Wed Mar 01 00:00:00 UTC 2023

A cytosolic surveillance mechanism activates the mitochondrial UPR.

Nature

Sutandy FXR,Gößner I,Tascher G,Münch C

Thu Jun 01 00:00:00 UTC 2023

A cytosolic surveillance mechanism activates the mitochondrial UPR.

Nature

Sutandy FXR,Gößner I,Tascher G,Münch C

Thu Jun 01 00:00:00 UTC 2023

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

Nature communications

Zhang J,Gan Y,Li H,Yin J,He X,Lin L,Xu S,Fang Z,Kim BW,Gao L,Ding L,Zhang E,Ma X,Li J,Li L,Xu Y,Horne D,Xu R,Yu H,Gu Y,Huang W

Fri May 20 00:00:00 UTC 2022

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

Nature communications

Zhang J,Gan Y,Li H,Yin J,He X,Lin L,Xu S,Fang Z,Kim BW,Gao L,Ding L,Zhang E,Ma X,Li J,Li L,Xu Y,Horne D,Xu R,Yu H,Gu Y,Huang W

Fri May 20 00:00:00 UTC 2022

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition.

Nature cell biology

Lu S,Hu J,Arogundade OA,Goginashvili A,Vazquez-Sanchez S,Diedrich JK,Gu J,Blum J,Oung S,Ye Q,Yu H,Ravits J,Liu C,Yates JR,Cleveland DW

Thu Sep 01 00:00:00 UTC 2022

Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.

Cancers

Alalem M,Bhosale M,Ranjan A,Yamamoto S,Kaida A,Nishikawa S,Parrales A,Farooki S,Anant S,Padhye S,Iwakuma T

Mon Aug 29 00:00:00 UTC 2022

Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.

Cancers

Alalem M,Bhosale M,Ranjan A,Yamamoto S,Kaida A,Nishikawa S,Parrales A,Farooki S,Anant S,Padhye S,Iwakuma T

Mon Aug 29 00:00:00 UTC 2022

Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.

The Journal of clinical investigation

Zhang Y,Yu H,Zhang J,Gao H,Wang S,Li S,Wei P,Liang J,Yu G,Wang X,Li X,Li D,Yang W

Mon Nov 01 00:00:00 UTC 2021

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction.

Molecular therapy. Nucleic acids

Pan J,Ma N,Zhong J,Yu B,Wan J,Zhang W

Fri Dec 03 00:00:00 UTC 2021

Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.

Scientific reports

Rodríguez-González C,Lin S,Arkan S,Hansen C

Mon May 18 00:00:00 UTC 2020

DjA1 maintains Golgi integrity via interaction with GRASP65.

Molecular biology of the cell

Li J,Tang D,Ireland SC,Wang Y

Fri Feb 15 00:00:00 UTC 2019

DjA1 maintains Golgi integrity via interaction with GRASP65.

Molecular biology of the cell

Li J,Tang D,Ireland SC,Wang Y

Fri Feb 15 00:00:00 UTC 2019

A cytosolic chaperone complex controls folding and degradation of type III CD38.

The Journal of biological chemistry

Wu Y,Zhang J,Fang L,Lee HC,Zhao YJ

Fri Mar 15 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; h HSJ-2; hDj-2; Heat shock 40 kDa protein 4; Heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ-2; Human DnaJ protein 2; neural precursor cell expressed, developmentally down-regulated 7; neural precursor cell expressed, developmentally down-regulated gene 7

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Gene Aliases: DJ-2; DjA1; DNAJ2; DNAJA1; hDJ-2; HDJ2; HSDJ; HSJ-2; HSJ2; HSPF4; NEDD7

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UniProt ID: (Human) P31689, (Mouse) P63037

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Entrez Gene ID: (Human) 3301, (Mouse) 15502

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Function(s)

G-protein coupled receptor binding protein binding ATP binding Hsp70 protein binding Tat protein binding ubiquitin protein ligase binding metal ion binding low-density lipoprotein particle receptor binding unfolded protein binding chaperone binding C3HC4-type RING finger domain binding heat shock protein binding

Process(es)

protein folding spermatogenesis response to heat sperm motility androgen receptor signaling pathway negative regulation of protein ubiquitination protein refolding DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity regulation of protein transport protein localization to mitochondrion toxin transport response to unfolded protein negative regulation of establishment of protein localization to mitochondrion negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DNAJA1 Polyclonal Antibody

DNAJA1 Antibody (11713-1-AP) in ICC/IF

Product Details

11713-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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