Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
22652-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNASE2B Fusion Protein Ag18246 (1-361 aa encoded by BC126136)
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MMARLLRTS FALLFLGLFG VLGAATISCR NEEGKAVDWF TFYKLPKKQN KESGETGLEY LYLDSTTRSW RKSEQLMNDT KSVLGRTLQQ LYEAYASKSN NTAYLIYNDG VPKPVNYSRK YGHTKGLLLW NRVQGFWLIH SIPQFPPIPE EGYDYPPTGR RNGQSGICIT FKYNQYEAID SQLLVCNPNV YSCSIPATFH QELIHMPQLC TRASSSEIPG RLLTTLQSAQ GQKFLHFAKS DSFLDDIFAA WMAQRLKTHL LTETWQRKRQ ELPSNCSLPY HVYNIKAIKL SRHSYFSSYQ DHAKWCISQK GTKNRWTCIG DLNRSPHQAF RSGGFICTQN WQIYQAFQGL VLYYESCK (1-361 aa encoded by BC126136)
Target Information
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deoxyribonuclease II beta; Deoxyribonuclease-2-beta; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; Endonuclease DLAD; lysosomal DNase II
Gene Aliases: DLAD; DNASE2B
UniProt ID: (Human) Q8WZ79
Entrez Gene ID: (Human) 58511
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support