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Proteintech
DNER Polyclonal Antibody
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Product Details
24362-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EPGYSCTCPA GISGANCQLV ADPCASNPCH HGNCSSSSSS SSDGYLCICN EGYEGPNCEQ ALPSLPATGW TESMAPRQLQ PVPATQEPDK ILPRSQATVT LPTWQPKTGQ KVVEMKWDQV EVIPDIACGN ASSNSSAGGR LVSFEVPQNT SVKIRQDATA SLILLWKVTA TGFQQCSLID GRSVTPLQAS GGLVLLEEML ALGNNHFIGF VNDSVTKSIV ALRLTLVVKV STCVPGESHA NDLECSGKGK CTTKPSEATF SCTCEEQYVG TFCEEYDACQ RKPCQNNASC IDANEKQDGS NFTCVCLPGY TGE
Target Information
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain EGF repeat-containing transmembrane protein; Delta and Notch-like epidermal growth factor-related receptor; delta-notch-like EGF repeat-containing transmembrane; delta/notch-like EGF repeat containing; H_NH0150O02.1; transmembrane protein Bet; WUGSC:H_NH0150O02.1
Gene Aliases: A930026D19Rik; BET; Bret; DNER; UNQ26; UNQ262/PRO299
UniProt ID: (Human) Q8NFT8, (Mouse) Q8JZM4
Entrez Gene ID: (Human) 92737, (Mouse) 227325
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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