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Proteintech
DNM2 Polyclonal Antibody
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Product Details
14605-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNM2 Fusion Protein Ag6156 (518-866 aa encoded by BC054501)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RRGWLTINN ISLMKGGSKE YWFVLTAESL SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR PPAAPSRPTI IRPAEPSLLD (518-866 aa encoded by BC054501)
Target Information
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dynamin 2; Dynamin II; Dynamin UDNM; Dynamin-2
Gene Aliases: b2b2159Clo; CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYIIAAB; DYN2; DYNII; LCCS5; Udnm
UniProt ID: (Human) P50570, (Rat) P39052, (Mouse) P39054
Entrez Gene ID: (Human) 1785, (Rat) 25751, (Mouse) 13430
GTPase activity
protein binding
GTP binding
microtubule binding
SH3 domain binding
enzyme binding
protein kinase binding
D2 dopamine receptor binding
protein complex binding
phosphatidylinositol 3-kinase regulatory subunit binding
WW domain binding
nitric-oxide synthase binding
nucleotide binding
hydrolase activity
G-protein coupled receptor internalization
Golgi to plasma membrane transport
endocytosis
receptor-mediated endocytosis
spermatogenesis
metabolic process
response to light stimulus
positive regulation of lamellipodium assembly
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of axon extension
receptor internalization
transferrin transport
regulation of Rac protein signal transduction
response to cocaine
macropinocytosis
positive regulation of nitric oxide biosynthetic process
positive regulation of endocytosis
neuron projection morphogenesis
positive regulation of phagocytosis
cilium morphogenesis
cellular response to carbon monoxide
cellular response to X-ray
cellular response to nitric oxide
positive regulation of substrate adhesion-dependent cell spreading
cellular response to dopamine
regulation of Golgi organization
positive regulation of sodium:potassium-exchanging ATPase activity
negative regulation of membrane tubulation
G2/M transition of mitotic cell cycle
ventricular septum development
regulation of transcription, DNA-templated
phagocytosis
signal transduction
antigen processing and presentation of exogenous peptide antigen via MHC class II
aorta development
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
synaptic vesicle transport
regulation of nitric-oxide synthase activity
coronary vasculature development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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