Proteintech

DNM3 Polyclonal Antibody

DNM3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

DNM3 Antibody (14737-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using 14737-1-AP (DNM3 antibody) at dilution of 1:50 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

DNM3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14737-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DNM3 Fusion Protein Ag6381 (206-555 aa encoded by BC064546)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Western blot using this antibody specifically detected the 100 kDa DNM3 in mouse brain. It doesn't cross-react with other DNMs.

Immunogen sequence: KLDLMDEGT DARDVLENKL LPLRRGYVGV VNRSQKDIDG KKDIKAAMLA ERKFFLSHPA YRHIADRMGT PHLQKVLNQQ LTNHIRDTLP NFRNKLQGQL LSIEHEVEAY KNFKPEDPTR KTKALLQMVQ QFAVDFEKRI EGSGDQVDTL ELSGGAKINR IFHERFPFEI VKMEFNEKEL RREISYAIKN IHGIRTGLFT PDMAFEAIVK KQIVKLKGPS LKSVDLVIQE LINTVKKCTK KLANFPRLCE ETERIVANHI REREGKTKDQ VLLLIDIQVS YINTNHEDFI GFANAQQRSS QVHKKTTVGN QVIRKGWLTI SNIGIMKGGS KGYWFVLTAE SLSWYKDDEN I (206-555 aa encoded by BC064546)

Target Information

The dynamins are a family of 100 kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is thought to be restricted to expression in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.

Oncology letters

Fa J

Thu Jul 01 00:00:00 UTC 2021

Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.

Oncology letters

Fa J

Thu Jul 01 00:00:00 UTC 2021

Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.

Oncology letters

Fa J

Thu Jul 01 00:00:00 UTC 2021

siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.

Cancer management and research

Ma Y,Guan L,Han Y,Zhou Y,Li X,Liu Y,Zhang X,Zhang W,Li X,Wang S,Lu W

Thu Oct 01 00:00:00 UTC 2020

Modification of Crocodile Spermatozoa Refutes the Tenet That Post-testicular Sperm Maturation Is Restricted To Mammals.

Molecular & cellular proteomics : MCP

Nixon B,Johnston SD,Skerrett-Byrne DA,Anderson AL,Stanger SJ,Bromfield EG,Martin JH,Hansbro PM,Dun MD

Fri Mar 15 00:00:00 UTC 2019

Modification of Crocodile Spermatozoa Refutes the Tenet That Post-testicular Sperm Maturation Is Restricted To Mammals.

Molecular & cellular proteomics : MCP

Nixon B,Johnston SD,Skerrett-Byrne DA,Anderson AL,Stanger SJ,Bromfield EG,Martin JH,Hansbro PM,Dun MD

Fri Mar 15 00:00:00 UTC 2019

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.

Molecular human reproduction

Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

Sun Oct 01 00:00:00 UTC 2017

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.

Molecular human reproduction

Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

Sun Oct 01 00:00:00 UTC 2017

Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.

Biology of reproduction

Zhou W,De Iuliis GN,Turner AP,Reid AT,Anderson AL,McCluskey A,McLaughlin EA,Nixon B

Sun Jan 01 00:00:00 UTC 2017

Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.

Biology of reproduction

Zhou W,De Iuliis GN,Turner AP,Reid AT,Anderson AL,McCluskey A,McLaughlin EA,Nixon B

Sun Jan 01 00:00:00 UTC 2017

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Clinical & experimental metastasis

Marino N,Collins JW,Shen C,Caplen NJ,Merchant AS,Gökmen-Polar Y,Goswami CP,Hoshino T,Qian Y,Sledge GW,Steeg PS

Wed Oct 01 00:00:00 UTC 2014

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Clinical & experimental metastasis

Marino N,Collins JW,Shen C,Caplen NJ,Merchant AS,Gökmen-Polar Y,Goswami CP,Hoshino T,Qian Y,Sledge GW,Steeg PS

Wed Oct 01 00:00:00 UTC 2014

Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.

The Journal of biological chemistry