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Abnova
DNMBP Polyclonal Antibody, MaxPab™
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Product Details
H00023268-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNMBP (AAH41628.1, 1 a.a. approximately 823 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTLLSSQSSS LVAPSGSVSA ENPEQRMLEK RAKVIEELLQ TERDYIRDLE MCIERIMVPM QQAQVPNIDF EGLFGNTQMV IKVSKQLLAA LEISDAVGPV FLGHRDELEG TYKIYCQNHD EAIALLEIYE KDEKIQKHLQ DSLADLKSLY NEWGCTNYIN LGSFLIKPVQ RVMRYPLLLM ELLNSTPESH PDKVPLTNAV LAVKEINVNI NEYKRRKDLV LKYRKGDEDS LMEKISKLNI HSIIKKSNRV SSHLKHLTGF APQIKDEVFE ETEKNFRMQE RLIKSFIRDL SLYLQHIRES ACVKVVAAVS MWDVCMERGH RDLEQFERVH RYISDQLFTN FKERTERLVI SPLNQLLSMF TGPHKLVQKR FDKLLDFYNC TERAEKLKDK KTLEELQSAR NNYEALNAQL LDELPKFHQY AQGLFTNCVH GYAEAHCDFV HQALEQLKPL LSLLKVAGRE GNLIAIFHEE HSRVLQQLQV FTFFPESLPA TKKPFERKTI DRQSARKPLL GLPSYMLQSE ELRASLLARY PPEKLFQAER NFNAAQDLDV SLLEGDLVGV IKKKDPMGSQ NRWLIDNGVT KGFVYSSFLK PYNPRRSHSD ASVGSHSSTE SEHGSSSPRF PRQNSGSTLT FNPSSMAVSF TSGSCQKQPQ DASPPPKEWD QGTLSASLNP SNSESSPSRC PSDPDSTSQP RSGDSADVAR DVKQPTATPR SYRNFRHPEI VGYSVPGRNG QSQDLVKGCA RTAQAPEDRS TEPDGSEAEG NQVYFAVYTF KARNPNELSV SANQKLKILE FKDVTGNTEW WLAEVNGKKG YVPSNYIRKT EYT
Target Information
The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dynamin-binding protein; Scaffold protein Tuba
Gene Aliases: ARHGEF36; DNMBP; KIAA1010; TUBA
UniProt ID: (Human) Q6XZF7
Entrez Gene ID: (Human) 23268
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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