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Invitrogen
DNMT2 Polyclonal Antibody
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FIGURE: 1 / 1
DNMT2 Antibody (PA5-87964) in WB
Western blot analysis of DNMT2 in extracts of various cell lines. Samples were incubated with DNMT2 Polyclonal antibody (Product # PA5-87964) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-87964
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 192-391 of human TRDMT1 (NP_0044031)
Conjugate
Form
Liquid
Concentration
1.64 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804546
Product Specific Information
Immunogen sequence: VHPQKYAMDV ENKIQEKNVE PNISFDGSIQ CSGKDAILFK LETAEEIHRK NQQDSDLSVK MLKDFLEDDT DVNQYLLPPK SLLRYALLLD IVQPTCRRSV CFTKGYGSYI EGTGSVLQTA EDVQVENIYK SLTNLSQEEQ ITKLLILKLR YFTPKEIANL LGFPPEFGFP EKITVKQRYR LLGNSLNVHV VAKLIKILYE; Positive Samples: SKOV3, 293T, DU145, HeLa, H460; Cellular Location: Nucleus
Target Information
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA (cytosine-5)-methyltransferase-like protein 2; DNA cytosine-5 methyltransferase 2; DNA methyltransferase homolog HsaIIP; DNA methyltransferase-2; DNA MTase homolog HsaIIP; Dnmt2; M.HsaIIP; PuMet; RP11-406H21.1; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase
Gene Aliases: DMNT2; DNMT2; MHSAIIP; PUMET; RNMT1; TRDMT1
UniProt ID: (Human) O14717
Entrez Gene ID: (Human) 1787
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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