Proteintech

DOC2B Polyclonal Antibody

DOC2B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

DOC2B Antibody (20574-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using DOC2B antibody 20574-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

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Product Details

20574-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1200

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to DOC2B.

Target Information

There are at least two protein isoforms of the Double C2 protein, namely alpha and beta, which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca-dependent intracellular vesicle trafficking in various types of cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function.

Free radical biology & medicine

Adiga D,Bhat S,Shukla V,Shah HV,Kuthethur R,Chakrabarty S,Kabekkodu SP

Sat May 20 00:00:00 UTC 2023

Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function.

Free radical biology & medicine

Adiga D,Bhat S,Shukla V,Shah HV,Kuthethur R,Chakrabarty S,Kabekkodu SP

Sat May 20 00:00:00 UTC 2023

DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer.

Pharmacological research

Adiga D,Bhat S,Chakrabarty S,Kabekkodu SP

Wed Jun 01 00:00:00 UTC 2022

DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer.

Pharmacological research

Adiga D,Bhat S,Chakrabarty S,Kabekkodu SP

Wed Jun 01 00:00:00 UTC 2022

Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence.

Cell biology and toxicology

Bhat S,Adiga D,Shukla V,Guruprasad KP,Kabekkodu SP,Satyamoorthy K

Fri Apr 01 00:00:00 UTC 2022

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.

Diabetes

Aslamy A,Oh E,Olson EM,Zhang J,Ahn M,Moin ASM,Tunduguru R,Salunkhe VA,Veluthakal R,Thurmond DC

Sun Jul 01 00:00:00 UTC 2018

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.

Diabetes

Aslamy A,Oh E,Olson EM,Zhang J,Ahn M,Moin ASM,Tunduguru R,Salunkhe VA,Veluthakal R,Thurmond DC

Sun Jul 01 00:00:00 UTC 2018

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.

Diabetes

Aslamy A,Oh E,Olson EM,Zhang J,Ahn M,Moin ASM,Tunduguru R,Salunkhe VA,Veluthakal R,Thurmond DC

Sun Jul 01 00:00:00 UTC 2018

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.

Diabetes

Aslamy A,Oh E,Olson EM,Zhang J,Ahn M,Moin ASM,Tunduguru R,Salunkhe VA,Veluthakal R,Thurmond DC

Sun Jul 01 00:00:00 UTC 2018

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.

The Journal of biological chemistry

Kabekkodu SP,Bhat S,Radhakrishnan R,Aithal A,Mascarenhas R,Pandey D,Rai L,Kushtagi P,Mundyat GP,Satyamoorthy K

Fri Apr 11 00:00:00 UTC 2014

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.

The Journal of biological chemistry

Kabekkodu SP,Bhat S,Radhakrishnan R,Aithal A,Mascarenhas R,Pandey D,Rai L,Kushtagi P,Mundyat GP,Satyamoorthy K

Fri Apr 11 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Doc2-beta; double C2 protein beta; double C2, beta; Double C2-like domain-containing protein beta; double C2-like domains, beta; OTTMUSP00000006522

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Gene Aliases: DOC2B; DOC2BL

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UniProt ID: (Human) Q14184, (Mouse) P70169, (Rat) P70610

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Entrez Gene ID: (Human) 8447, (Mouse) 13447, (Rat) 81820

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Function(s)

calcium ion binding calcium-dependent phospholipid binding syntaxin binding clathrin binding protein binding transporter activity

Process(es)

vesicle fusion protein localization regulation of calcium ion-dependent exocytosis positive regulation of vesicle fusion positive regulation of insulin secretion positive regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter synaptic vesicle exocytosis exocytosis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DOC2B Polyclonal Antibody

DOC2B Antibody (20574-1-AP) in ICC/IF

Product Details

20574-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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