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DOCK1 Antibody (PA5-101550) in IHC (P)
Immunohistochemistry analysis of DOCK1 in human colorectal cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DOCK1 polyclonal antibody (Product # PA5-101550) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DOCK1(Accession Q14185), corresponding to amino acid residues R1661-E1711.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850984
Product Specific Information
Antibody detects endogenous levels of total DOCK1.
Target Information
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 180 kDa protein downstream of CRK; dedicator of cyto-kinesis 1; Dedicator of cytokinesis protein 1; dock 180; DOCK180; DOwnstream of CrK; RP11-82L9.1
Gene Aliases: 9130006G06Rik; AI854900; ced5; D630004B07Rik; DOCK1; DOCK180; RGD1566072
UniProt ID: (Human) Q14185, (Mouse) Q8BUR4
Entrez Gene ID: (Human) 1793, (Mouse) 330662, (Rat) 309081
hematopoietic progenitor cell differentiation
phagocytosis
apoptotic process
small GTPase mediated signal transduction
cell migration
phagocytosis, engulfment
cytoskeleton organization
signal transduction
integrin-mediated signaling pathway
blood coagulation
positive regulation of epithelial cell migration
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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