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Proteintech
DOCK10 Polyclonal Antibody
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Product Details
16834-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DOCK10 Fusion Protein Ag10486 (194-542 aa encoded by BC015018)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AVFEKQRDF KKLSDLYYDI HRSYLKVAEV VNSEKRLFGR YYRVAFYGQG FFEEEEGKEY IYKEPKLTGL SEISQRLLKL YADKFGADNV KIIQDSNKVN PKDLDPKYAY IQVTYVTPFF EEKEIEDRKT DFEMHHNINR FVFETPFTLS GKKHGGVAEQ CKRRTILTTS HLFPYVKKRI QVISQSSTEL NPIEVAIDEM SKKVSELNQL CTMEEVDMIR LQLKLQGSVS VKVNAGPMAY ARAFLEETNA KKYPDNQVKL LKEIFRQFAD ACGQALDVNE RLIKEDQLEY QEELRSHYKD MLSELSTVMN EQITGRDDLS KRGVDQTCTR VISKATPALP TVSISSSAEV (194-542 aa encoded by BC015018)
Target Information
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dedicator of cytokinesis 10; Dedicator of cytokinesis protein 10; dopamine receptor interacting protein 2; Zizimin-3; zizimin3
Gene Aliases: 9330153B10Rik; A630054M16Rik; DOCK10; DRIP2; Jr4; Jr5; KIAA0694; mKIAA0694; Nbla10300; R75174; RGD1561963; ZIZ3; Zizimin3
UniProt ID: (Human) Q96BY6, (Mouse) Q8BZN6
Entrez Gene ID: (Human) 55619, (Mouse) 210293, (Rat) 301556
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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