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DOCK3 Antibody (PA5-47902) in IHC (P)
Immunohistochemical analysis of DOCK3 in immersion fixed paraffin-embedded sections of human Alzheimers brain (cortex). Samples were incubated in DOCK3 polyclonal antibody (Product # PA5-47902) using a dilution of 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hemotoxylin (blue). Specific staining was localized to neurofi... View More
Product Details
PA5-47902
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human DOCK3 Gly418-Thr656
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606777
Product Specific Information
In direct ELISAs, less than 3% cross-reactivity with recombinant human (rh) DOCK1, rhDOCK2, and rhDOCK5 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dedicator of cytokinesis protein 3; dok-3; Modifier of cell adhesion; PBP; Presenilin-binding protein
Gene Aliases: DOCK3; KIAA0299; MOCA; PBP
UniProt ID: (Human) Q8IZD9
Entrez Gene ID: (Human) 1795
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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