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Product Details
29938-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ILEPLLERRA SSGARVEDLS LREENSENRI SKFKRKDWSL SKSQVIAEKA PEPDLMSPTR KAQRPKSLQL MDNRLSPFHG SSPPQSTPLS PPPLTPKATR TLSSPSLQTD GIAATPVPPP PPPKSKPYEG SQRNSTELAP PLPVRREAKA PPPPPPKARK SGIPTSEPGS Q
Target Information
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dedicator of cytokinesis protein 5; dock5; FLJ21034; lens rupture 2; Lens rupture protein 2; Rupture of lens cataract protein
Gene Aliases: 1110060D06Rik; AI666732; AI956923; BC016533; DOCK5; E130320D18; Lr2; Rlc
UniProt ID: (Human) Q9H7D0, (Mouse) B2RY04
Entrez Gene ID: (Human) 80005, (Mouse) 68813, (Rat) 305987
small GTPase mediated signal transduction
positive regulation of GTPase activity
positive regulation of epithelial cell migration
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of vascular smooth muscle contraction
positive regulation of vascular associated smooth muscle cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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