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Invitrogen
DOCK5 Polyclonal Antibody
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Product Details
PA5-66045
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human DOCK5. Recombinant protein control fragment (Product #RP-106733).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2664784
Product Specific Information
Immunogen sequence: VELSVLFCKFI QSIPDNQLVR QKLNCMTKIV ESTLFRQSEC REVLLPLLTD QLSGQLDDNS NKPDHEASSQ LL
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Target Information
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dedicator of cytokinesis protein 5; FLJ21034
Gene Aliases: DOCK5
UniProt ID: (Human) Q9H7D0
Entrez Gene ID: (Human) 80005
small GTPase mediated signal transduction
positive regulation of epithelial cell migration
positive regulation of GTPase activity
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of vascular smooth muscle contraction
positive regulation of vascular associated smooth muscle cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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