Proteintech

DOM3Z Polyclonal Antibody

DOM3Z Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DOM3Z Antibody (11015-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 11015-2-AP (DOM3Z antibody) at dilution of 1:50 (under 25x lens).

DOM3Z Antibody in Immunoprecipitation (IP)

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Product Details

11015-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DOM3Z Fusion Protein Ag1491 (1-396 aa encoded by BC009344)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDPRGTKRG AEKTEVAEPR NKLPRPAPSL PTDPALYSGP FPFYRRPSEL GCFSLDAQRQ YHGDARALRY YSPPPTNGPG PNFDLRDGYP DRYQPRDEEV QERLDHLLCW LLEHRGRLEG GPGWLAEAIV TWRGHLTKLL TTPYERQEGW QLAASRFQGT LYLSEVETPN ARAQRLARPP LLRELMYMGY KFEQYMCADK PGSSPDPSGE VNTNVAFCSV LRSRLGSHPL LFSGEVDCTD PQAPSTQPPT CYVELKTSKE MHSPGQWRSF YRHKLLKWWA QSFLPGVPNV VAGFRNPDGF VSSLKTFPTM KMFEYVRNDR DGWNPSVCMN FCAAFLSFAQ STVVQDDPRL VHLFSWEPGG PVTVSVHQDA PYAFLPIWYV EAMTQDLPSP PKTPSPK (1-396 aa encoded by BC009344)

Target Information

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.

Nature chemical biology

Grudzien-Nogalska E,Wu Y,Jiao X,Cui H,Mateyak MK,Hart RP,Tong L,Kiledjian M

Sat Jun 01 00:00:00 UTC 2019

2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.

PloS one

Picard-Jean F,Brand C,Tremblay-Létourneau M,Allaire A,Beaudoin MC,Boudreault S,Duval C,Rainville-Sirois J,Robert F,Pelletier J,Geiss BJ,Bisaillon M

Tue Jun 26 00:00:00 UTC 2018

2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.

PloS one

Picard-Jean F,Brand C,Tremblay-Létourneau M,Allaire A,Beaudoin MC,Boudreault S,Duval C,Rainville-Sirois J,Robert F,Pelletier J,Geiss BJ,Bisaillon M

Tue Jun 26 00:00:00 UTC 2018

5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

Cell

Jiao X,Doamekpor SK,Bird JG,Nickels BE,Tong L,Hart RP,Kiledjian M

Thu Mar 09 00:00:00 UTC 2017

5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

Cell

Jiao X,Doamekpor SK,Bird JG,Nickels BE,Tong L,Hart RP,Kiledjian M

Thu Mar 09 00:00:00 UTC 2017

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

Molecular cell

Jiao X,Chang JH,Kilic T,Tong L,Kiledjian M

Thu Apr 11 00:00:00 UTC 2013

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

Molecular cell

Jiao X,Chang JH,Kilic T,Tong L,Kiledjian M

Thu Apr 11 00:00:00 UTC 2013

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.

RNA (New York, N.Y.)

Zheng D,Chen CY,Shyu AB

Thu Sep 01 00:00:00 UTC 2011

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.

RNA (New York, N.Y.)

Zheng D,Chen CY,Shyu AB

Thu Sep 01 00:00:00 UTC 2011

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.

RNA (New York, N.Y.)

Zheng D,Chen CY,Shyu AB

Thu Sep 01 00:00:00 UTC 2011

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.

RNA (New York, N.Y.)

Zheng D,Chen CY,Shyu AB

Thu Sep 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 5'-3' exoribonuclease DXO; Decapping and exoribonuclease protein; DeNADding enzyme DXO; Dom-3 homolog Z; DXO; NAD-capped RNA hydrolase DXO; protein Dom3Z

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Gene Aliases: DOM3L; DOM3Z; DXO; NG6; RAI1

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UniProt ID: (Human) O77932, (Rat) Q6MG77, (Mouse) O70348

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Entrez Gene ID: (Human) 1797, (Rat) 361799, (Mouse) 112403

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Function(s)

Process(es)

mRNA catabolic process biological_process metabolic process RNA destabilization nuclear mRNA surveillance nucleic acid phosphodiester bond hydrolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DOM3Z Polyclonal Antibody

DOM3Z Antibody (11015-2-AP) in IHC (P)

Product Details

11015-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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