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Invitrogen
DPYD Polyclonal Antibody
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Product Details
PA5-106882
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DPYD(Accession Q12882), corresponding to amino acid residues L775-T825.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854546
Product Specific Information
Antibody detects endogenous levels of total DPYD.
Target Information
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD
Gene Aliases: AI315208; DHP; DHPDHASE; DPD; DPYD; E330028L06Rik
UniProt ID: (Human) Q12882, (Rat) O89000, (Mouse) Q8CHR6
Entrez Gene ID: (Human) 1806, (Rat) 81656, (Mouse) 99586
protein binding
dihydropyrimidine dehydrogenase (NADP+) activity
protein homodimerization activity
metal ion binding
flavin adenine dinucleotide binding
NADP binding
4 iron, 4 sulfur cluster binding
uracil binding
dihydroorotate dehydrogenase activity
iron-sulfur cluster binding
nucleotide binding
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
thymine catabolic process
uracil catabolic process
thymidine catabolic process
beta-alanine biosynthetic process
pyrimidine nucleoside catabolic process
oxidation-reduction process
UMP biosynthetic process
response to nutrient
circadian rhythm
uracil metabolic process
response to drug
response to glucocorticoid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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