Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
DPYD Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
DPYD Antibody (PA5-109657) in WB
Western blot analysis of DPYD in extracts of various cell lines. Samples were incubated with DPYD Polyclonal antibody (Product # PA5-109657) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit.
Product Details
PA5-109657
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_0001012)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855068
Product Specific Information
Immunogen sequence: MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT ETLILAFSLM NHL
Target Information
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
Gene Aliases: AI315208; DHP; DHPDHASE; DPD; DPYD; E330028L06Rik
UniProt ID: (Human) Q12882, (Mouse) Q8CHR6
Entrez Gene ID: (Human) 1806, (Mouse) 99586
protein binding
dihydropyrimidine dehydrogenase (NADP+) activity
protein homodimerization activity
metal ion binding
flavin adenine dinucleotide binding
NADP binding
4 iron, 4 sulfur cluster binding
nucleotide binding
uracil binding
catalytic activity
dihydroorotate dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
iron-sulfur cluster binding
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
thymine catabolic process
uracil catabolic process
thymidine catabolic process
beta-alanine biosynthetic process
pyrimidine nucleoside catabolic process
oxidation-reduction process
UMP biosynthetic process
response to nutrient
circadian rhythm
uracil metabolic process
response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support