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Invitrogen
DPYSL3 Polyclonal Antibody
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DPYSL3 Antibody (PA5-119755) in WB
Western blot analysis of CRMP4 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. DPYSL3 Polyclonal Antibody (Product # PA5-119755) at 1:500 was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:5,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: Rat spinal cord tissue lysate. Lane 2: LO2 cell lysate.
Product Details
PA5-119755
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human CRMP4 1-50
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2913327
Product Specific Information
Positive Control: Rat spinal cord tissue lysate, LO2 cell lysate.
Subcellular Location: Cell projection, Cytoplasm.
Target Information
DPYSL3 is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. DPYSL3 plays a role in axon guidance, neuronal growth cone collapse and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collapsin response mediator protein 4; collapsin response mediator protein 4 long; CRMP-4; dihydropyrimidinase-like 3; Dihydropyrimidinase-related protein 3; DRP-3; testicular secretory protein Li 7; TOAD-64/Ulip/CRMP; TOAD-64/Ulip/CRMP protein 4b; tuc-4; TUC-4b; ULIP-1; Unc-33-like phosphoprotein 1
Gene Aliases: CRMP-4; CRMP4; DPYSL3; DRP-3; DRP3; LCRMP; TUC-4b; TUC4; ULIP; ULIP-1; ULIP1
UniProt ID: (Human) Q14195, (Mouse) Q62188, (Rat) Q62952
Entrez Gene ID: (Human) 1809, (Mouse) 22240, (Rat) 25418
nervous system development
positive regulation of neuron projection development
negative regulation of neuron projection development
negative regulation of cell migration
actin filament bundle assembly
protein homooligomerization
positive regulation of filopodium assembly
actin crosslink formation
neuron development
response to axon injury
cellular response to cytokine stimulus
pyrimidine nucleobase catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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