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Proteintech
DR1 Polyclonal Antibody
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Product Details
10406-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DR1 Fusion Protein Ag0664 (1-176 aa encoded by BC002809)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASSSGNDD DLTIPRAAIN KMIKETLPNV RVANDARELV VNCCTEFIHL ISSEANEICN KSEKKTISPE HVIQALESLG FGSYISEVKE VLQECKTVAL KRRKASSRLE NLGIPEEELL RQQQELFAKA RQQQAELAQQ EWLQMQQAAQ QAQLAAASAS ASNQAGSSQD EEDDDDI (1-176 aa encoded by BC002809)
Target Information
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2-beta; negative cofactor 2; negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
Gene Aliases: 1700121L09Rik; DR1; Dr1l; NC2; NC2-BETA; NC2B; NC2beta
UniProt ID: (Human) Q01658, (Mouse) Q91WV0, (Rat) Q5XI68
Entrez Gene ID: (Human) 1810, (Mouse) 13486, (Rat) 289881
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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