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Product Details
OSD00045W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of rat DR6 (Death receptor 6) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: DR6.
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD358; Death receptor 6; Death receptor-6; MGC31965; sCD358; sDR6; soluble CD358; soluble DR6; TNFR-related death receptor 6; TNFR-related death receptor-6; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Aliases: AA959878; BM-018; CD358; DR6; R74815; TNFRSF21; TR7; UNQ437/PRO868
UniProt ID: (Human) O75509, (Mouse) Q9EPU5, (Rat) D3ZF92
Entrez Gene ID: (Human) 27242, (Mouse) 94185, (Rat) 316256
B cell apoptotic process
adaptive immune response
immune system process
apoptotic process
humoral immune response
signal transduction
negative regulation of B cell proliferation
negative regulation of myelination
negative regulation of T cell proliferation
myelination
regulation of oligodendrocyte differentiation
T cell receptor signaling pathway
neuron apoptotic process
cellular response to tumor necrosis factor
oligodendrocyte apoptotic process
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
negative regulation of interleukin-10 secretion
inflammatory response
immune response
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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