Invitrogen

DRD1 Polyclonal Antibody

View all (30) DRD1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-33478

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

8 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Dog, Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 15 amino acid peptide from 3rd cytoplasmic domain of human DRD1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550858

Product Specific Information

This antibody is not recommended for use in ICC applications.

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bovine, Pig, Opossum (100%).

Target Information

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(1A) dopamine receptor; D1a dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor

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Gene Aliases: BOS_10121; D1AR; DADR; DRD1; DRD1A

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UniProt ID: (Bovine) Q95136, (Human) P21728, (Pig) P50130

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Entrez Gene ID: (Bovine) 281125, (Human) 1812, (Pig) 100144487, (Dog) 489110

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs dopamine binding G-protein alpha-subunit binding dopamine neurotransmitter receptor activity protein binding drug binding protein phosphatase binding angiotensin receptor binding D3 dopamine receptor binding protein complex binding protein heterodimerization activity ATPase binding
Process(es)
temperature homeostasis conditioned taste aversion behavioral fear response synaptic transmission, dopaminergic response to amphetamine protein import into nucleus activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway memory mating behavior grooming behavior adult walking behavior visual learning positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway astrocyte development dopamine transport neuronal action potential dentate gyrus development striatum development cerebral cortex GABAergic interneuron migration positive regulation of cell migration peristalsis operant conditioning regulation of dopamine metabolic process vasodilation response to drug glucose import sensitization behavioral response to cocaine positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway long-term synaptic potentiation long term synaptic depression cellular response to catecholamine stimulus negative regulation of protein kinase activity G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway synapse assembly learning response to activity transmission of nerve impulse regulation of vasoconstriction calcium-mediated signaling orbitofrontal cortex development negative regulation of cell migration positive regulation of cAMP biosynthetic process response to food response to estradiol response to retinoic acid cellular response to insulin stimulus response to nicotine social behavior response to antidepressant negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process maternal behavior response to amino acid positive regulation of potassium ion transport response to morphine response to ethanol positive regulation of membrane potential habituation regulation of long-term neuronal synaptic plasticity response to steroid hormone regulation of dopamine uptake involved in synaptic transmission prepulse inhibition cellular response to hypoxia positive regulation of long-term synaptic potentiation positive regulation of feeding behavior
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