Invitrogen

DRD1 Recombinant Rabbit Monoclonal Antibody (JM10-93)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-42467

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM10-93

Immunogen

Synthetic peptide within C-terminal human DRD1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911608

Product Specific Information

Positive Control: Mouse kidney tissue lysates, 293T, N2A, SH-SY5Y, mouse brain tissue, rat brain tissue.

Subcellular Location: Cell membrane. Endoplasmic reticulum membrane.

Target Information

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(1A) dopamine receptor; D1 receptor; D1A dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; dopamine receptor D1A; Dopamine-1A receptor; G protein-coupled receptor DRD1

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Gene Aliases: C030036C15Rik; D1a; DADR; Drd-1; DRD1; DRD1A; Gpcr15

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UniProt ID: (Human) P21728, (Mouse) Q61616

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Entrez Gene ID: (Human) 1812, (Mouse) 13488, (Rat) 24316

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding dopamine neurotransmitter receptor activity protein binding drug binding protein phosphatase binding angiotensin receptor binding D3 dopamine receptor binding protein complex binding dopamine binding protein heterodimerization activity ATPase binding signal transducer activity G-protein coupled receptor activity receptor binding G-protein coupled amine receptor activity
Process(es)
temperature homeostasis conditioned taste aversion behavioral fear response synaptic transmission, dopaminergic response to amphetamine negative regulation of protein kinase activity protein import into nucleus G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway synapse assembly learning memory mating behavior grooming behavior adult walking behavior visual learning positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway astrocyte development response to activity dopamine transport transmission of nerve impulse neuronal action potential regulation of vasoconstriction calcium-mediated signaling dentate gyrus development striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration positive regulation of cell migration negative regulation of cell migration peristalsis positive regulation of cAMP biosynthetic process response to food response to estradiol response to retinoic acid cellular response to insulin stimulus response to nicotine operant conditioning social behavior response to antidepressant regulation of dopamine metabolic process vasodilation negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process response to drug maternal behavior response to amino acid positive regulation of potassium ion transport response to morphine response to ethanol positive regulation of membrane potential glucose import habituation sensitization behavioral response to cocaine regulation of long-term neuronal synaptic plasticity response to steroid hormone positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of dopamine uptake involved in synaptic transmission positive regulation of synaptic transmission, glutamatergic prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway long-term synaptic potentiation long term synaptic depression cellular response to hypoxia cellular response to catecholamine stimulus positive regulation of long-term synaptic potentiation positive regulation of feeding behavior startle response intracellular protein transport muscle contraction signal transduction G-protein coupled receptor signaling pathway dopamine receptor signaling pathway chemical synaptic transmission sensory perception of chemical stimulus locomotory behavior feeding behavior associative learning hippocampus development phosphatidylinositol catabolic process response to cocaine regulation of ion transport positive regulation of adenylate cyclase activity phosphatidylinositol metabolic process response to organonitrogen compound response to organic cyclic compound
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