Invitrogen

DRD3 Recombinant Rabbit Monoclonal Antibody (5B10)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38398

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5B10

Immunogen

A synthesized peptide derived from human Dopamine Receptor D3 (aa 19-33).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898312

Product Specific Information

This antibody has been tested in direct-ELISA

Target Information

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(3) dopamine receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopaminergic receptor D3; essential tremor 1

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Gene Aliases: D3DR; DRD3; ETM1; FET1

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UniProt ID: (Human) P35462, (Rat) P19020

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Entrez Gene ID: (Human) 1814, (Rat) 29238

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gi/Go protein binding drug binding protein domain specific binding D1 dopamine receptor binding dopamine binding dopamine neurotransmitter receptor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter synaptic transmission, dopaminergic response to amphetamine regulation of blood volume by renin-angiotensin G-protein coupled receptor internalization cellular calcium ion homeostasis G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway learning or memory learning locomotory behavior positive regulation of cell proliferation visual learning regulation of dopamine secretion regulation of lipid metabolic process regulation of cAMP metabolic process negative regulation of sodium:proton antiporter activity positive regulation of cytokinesis circadian regulation of gene expression response to histamine social behavior gastric emptying positive regulation of renal sodium excretion regulation of multicellular organism growth response to cocaine dopamine metabolic process response to drug response to morphine regulation of circadian sleep/wake cycle, sleep response to ethanol negative regulation of blood pressure positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter acid secretion behavioral response to cocaine negative regulation of oligodendrocyte differentiation arachidonic acid secretion negative regulation of protein secretion musculoskeletal movement, spinal reflex action regulation of dopamine uptake involved in synaptic transmission negative regulation of protein kinase B signaling prepulse inhibition negative regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of locomotion involved in locomotory behavior dopamine receptor signaling pathway chemical synaptic transmission regulation of locomotion
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