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Progen
DSC1 Monoclonal Antibody (Dsc1-U100)
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Product Details
61092PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Dsc1-U100
Immunogen
Synthetic Peptide Corresponding To Sequence Present Within The Intracellular Part Of Human Desmocollin 1 (Hqtlesvkgv gqgdtgryat dwqc)
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
Localizes Dsc1 present insuprabasal layers of interfollicular epidermisspecific cell layers (e.g. in hair follicle root sheath)Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).Reacts with 111 kD (form "a") and 103 kD (form "b") polypeptides (desmo-collin 1 splice forms, both at pI 5.2) from human epidermal desmosomes.Reactivity on cultured cell lines: Positive on primary keratinocytes, however, restricted to local piles of differentiated cells. All simple epithelia are negative.
Target Information
The desmosomal cadherin desmocollin DSC1 is expressed in upper epidermis where strong adhesion is required. DSC1 is a type I membrane protein (4) required for strong adhesion and barrier maintenance in epidermis and contributes to epidermal differentiation.The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 1; Desmocollin-1; Desmocollin1; Desmosomal glycoprotein 2/3; DG2/DG3
Gene Aliases: 1110020A10Rik; AI507491; CDHF1; DG2/DG3; DSC1; Dsc1a; Dsc1b
UniProt ID: (Human) Q08554, (Mouse) P55849
Entrez Gene ID: (Human) 1823, (Rat) 291759, (Mouse) 13505
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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