Proteintech

DSS1 Polyclonal Antibody

DSS1 Antibody in Immunocytochemistry (ICC/IF)

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DSS1 Antibody (13639-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using SHFM1 antibody 13639-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

DSS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

13639-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DSS1 Fusion Protein Ag4573 (1-70 aa encoded by BC032782)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEKKQPVD LGLLEEDDEF EEFPAEDWAG LDEDEDAHVW EDNWDDDNVE DDFSNQLRAE LEKHGYKMET S (1-70 aa encoded by BC032782)

Target Information

The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance.

Experimental and therapeutic medicine

Wu Y,Wang Z,Li S,Chen X,Zhou S

Mon May 01 00:00:00 UTC 2023

SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance.

Experimental and therapeutic medicine

Wu Y,Wang Z,Li S,Chen X,Zhou S

Mon May 01 00:00:00 UTC 2023

Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor.

Cell reports

Huang J,Zhong Y,Makohon-Moore AP,White T,Jasin M,Norell MA,Wheeler WC,Iacobuzio-Donahue CA

Tue May 03 00:00:00 UTC 2022

Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas.

Laboratory investigation; a journal of technical methods and pathology

Gondo N,Sakai Y,Zhang Z,Hato Y,Kuzushima K,Phimsen S,Kawashima Y,Kuroda M,Suzuki M,Okada S,Iwata H,Toyama T,Rezano A,Kuwahara K

Sun Aug 01 00:00:00 UTC 2021

DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.

Human pathology

Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

Wed Feb 01 00:00:00 UTC 2017

DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.

Human pathology

Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

Wed Feb 01 00:00:00 UTC 2017

DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.

Human pathology

Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

Wed Feb 01 00:00:00 UTC 2017

DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.

Human pathology

Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

Wed Feb 01 00:00:00 UTC 2017

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Nature

Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

Thu Jul 17 00:00:00 UTC 2014

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Nature

Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

Thu Jul 17 00:00:00 UTC 2014

DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.

Protein & cell

Zhang Y,Chang FM,Huang J,Junco JJ,Maffi SK,Pridgen HI,Catano G,Dang H,Ding X,Yang F,Kim DJ,Slaga TJ,He R,Wei SJ

Sat Feb 01 00:00:00 UTC 2014

DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.

Protein & cell

Zhang Y,Chang FM,Huang J,Junco JJ,Maffi SK,Pridgen HI,Catano G,Dang H,Ding X,Yang F,Kim DJ,Slaga TJ,He R,Wei SJ

Sat Feb 01 00:00:00 UTC 2014

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

Journal of medical genetics

Rattanasopha S,Tongkobpetch S,Srichomthong C,Kitidumrongsook P,Suphapeetiporn K,Shotelersuk V

Mon Dec 01 00:00:00 UTC 2014

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

Journal of medical genetics

Rattanasopha S,Tongkobpetch S,Srichomthong C,Kitidumrongsook P,Suphapeetiporn K,Shotelersuk V

Mon Dec 01 00:00:00 UTC 2014

Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival.

BMC cancer

Rezano A,Kuwahara K,Yamamoto-Ibusuki M,Kitabatake M,Moolthiya P,Phimsen S,Suda T,Tone S,Yamamoto Y,Iwase H,Sakaguchi N

Sun Dec 01 00:00:00 UTC 2013

Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival.

BMC cancer

Rezano A,Kuwahara K,Yamamoto-Ibusuki M,Kitabatake M,Moolthiya P,Phimsen S,Suda T,Tone S,Yamamoto Y,Iwase H,Sakaguchi N

Sun Dec 01 00:00:00 UTC 2013

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

The EMBO journal

Butler LR,Densham RM,Jia J,Garvin AJ,Stone HR,Shah V,Weekes D,Festy F,Beesley J,Morris JR

Wed Oct 03 00:00:00 UTC 2012

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

The EMBO journal

Butler LR,Densham RM,Jia J,Garvin AJ,Stone HR,Shah V,Weekes D,Festy F,Beesley J,Morris JR

Wed Oct 03 00:00:00 UTC 2012

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

The EMBO journal

Butler LR,Densham RM,Jia J,Garvin AJ,Stone HR,Shah V,Weekes D,Festy F,Beesley J,Morris JR

Wed Oct 03 00:00:00 UTC 2012

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

The EMBO journal

Butler LR,Densham RM,Jia J,Garvin AJ,Stone HR,Shah V,Weekes D,Festy F,Beesley J,Morris JR

Wed Oct 03 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: 26S proteasome complex subunit DSS1; 26S proteasome complex subunit SEM1; Deleted in split hand/split foot protein 1; deleted in split-hand/split-foot 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein

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Gene Aliases: C7orf76; DSS1; ECD; SEM1; SHFD1; SHFDG1; SHFM1; SHSF1

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UniProt ID: (Human) P60896

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Entrez Gene ID: (Human) 7979

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Function(s)

protein binding

Process(es)

double-strand break repair via homologous recombination mRNA export from nucleus proteolysis proteasome assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DSS1 Polyclonal Antibody

DSS1 Antibody (13639-1-AP) in ICC/IF

Product Details

13639-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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