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Invitrogen
DTX3L Monoclonal Antibody (K24022_3F7)
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DTX3L Antibody (MA5-55812) in WB
Western blot analysis of DTX3L in 15 µg of A-431. Sample was run on 6-18% SDS-PAGE under reducing conditions, blotted onto nitrocellulose membrane, and peroxidase conjugated goat anti-mouse IgG was used as the secondary antibody. DTX3L band was visualized using ECL Western Blotting Substrate. Incubation with primary DTX3L monoclonal antibody (Product # MA5-55812) at a dilution of 1 µg/mL was used.
Product Details
MA5-55812
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K24022_3F7
Immunogen
Recombinant human DTX3L (immunogen range is 21-120).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_3668044
Product Specific Information
Sequence of this protein is as follows: RVRRKLESYF QSSKSSGGGE CTVSTQEHEA PGTFRVEFSE RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ ISSLTQSQAE TPSGDMHQHE
Target Information
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; rhysin 2; Rhysin-2; Rhysin2; RING-type E3 ubiquitin transferase DTX3L
Gene Aliases: BBAP; DTX3L
UniProt ID: (Human) Q8TDB6
Entrez Gene ID: (Human) 151636
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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