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DUOX1 Antibody (PA5-85452) in IHC (P)
Immunohistochemistry analysis of DUOX1 in paraffin-embedded human gastric cancer. Samples were incubated with DUOX1 polyclonal antibody (Product # PA5-85452) using a dilution of 1:500. Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15 min.
Product Details
PA5-85452
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human DUOX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792592
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (89%), Rat (87%), Dog (86%), Pig (90%), Bovine (90%).
Positive Control: A549, H1299, HCT116, unboiled A431, A431 membrane extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual oxidase 1; flavoprotein NADPH oxidase; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; Thyroid oxidase 1
Gene Aliases: DUOX; DUOX1; LNOX1; NOXEF1; THOX1
UniProt ID: (Human) Q9NRD9
Entrez Gene ID: (Human) 53905
thyroid hormone generation
response to oxidative stress
cytokine-mediated signaling pathway
cuticle development
hormone biosynthetic process
superoxide anion generation
hydrogen peroxide catabolic process
hydrogen peroxide biosynthetic process
response to cAMP
oxidation-reduction process
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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