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Product Details
H00011266-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DUSP12 (NP_009171.1, 1 a.a. approximately 340 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLEAPGPSDG CELSNPSASR VSCAGQMLEV QPGLYFGGAA AVAEPDHLRE AGITAVLTVD SEEPSFKAGP GVEDLWRLFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS RSVAIITAFL MKTDQLPFEK AYEKLQILKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK QYRLQKVTEK YPELQNLPQE LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHREG SGPIAFAHKR MTPSSMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLGSQTGKI
Target Information
Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase; YVH1 protein-tyrosine phosphatase ortholog
Gene Aliases: DUSP1; DUSP12; YVH1
UniProt ID: (Human) Q9UNI6
Entrez Gene ID: (Human) 11266
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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