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Invitrogen
DUSP12 Polyclonal Antibody
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FIGURE: 1 / 1
DUSP12 Antibody (PA5-89113) in WB
Western blot analysis of DUSP12 in extracts of various cell lines. Samples were incubated with DUSP12 Polyclonal antibody (Product # PA5-89113) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-89113
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_0091711)
Conjugate
Form
Liquid
Concentration
2.54 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805364
Product Specific Information
Immunogen sequence: LMKTDQLPFE KAYEKLQILK PEAKMNEGFE WQLKLYQAMG YEVDTSSAIY KQYRLQKVTE KYPELQNLPQ ELFAVDPTTV SQGLKDEVLY KCRKCRRSLF RSSSILDHRE GSGPIAFAHK RMTPSSMLTT GRQAQCTSYF I; Positive Samples: Jurkat, A-549; Cellular Location: Nucleus
Target Information
Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity phosphatase T-DSP4; Dual specificity phosphatase VH1; Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase; YVH1 protein-tyrosine phosphatase ortholog
Gene Aliases: 1190004O14Rik; AA027408; AW049275; DUSP1; DUSP12; ESTM36; LMW-DSP4; mVH1; T-DSP4; VH1; YVH1
UniProt ID: (Human) Q9UNI6, (Mouse) Q9D0T2
Entrez Gene ID: (Human) 11266, (Mouse) 80915
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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