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Suggested positive control: human testis protein, human or rat testis lysate, rat testis protein.
DUSP18 (E.C 3.1.3.16), a novel DSP, is a member of highly conserved protein-tyrosine phosphatase super family. Members of this family cooperate with protein kinases and play a vital role in cell cycle regulation and mitogenic signal transduction. DUSP18 is a low molecular weight protein consisting of conserved N-terminal DSP domain but lacks CH2 domain. Studies reveal that DUSP18 is a unique DSP that interacts and dephosphorylates SAPK/JNK. Reports suggest it inhibits SAPK/JNK invivo and might serve an important role in the regulation of SAPK/JNK pathway. Northern Blot analysis detected a ubiquitous expression of DUSP18.
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Protein Aliases: bK963H5.1; Dual specificity protein phosphatase 18; LMW-DSP20; Low molecular weight dual specificity phosphatase 20
Gene Aliases: BOS_16774; DSP18; DUSP18; DUSP20; LMWDSP20
UniProt ID: (Human) Q8NEJ0, (Bovine) Q5BIP9
Entrez Gene ID: (Human) 150290, (Bovine) 505912
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