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Product Details
PA5-49882
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from internal of human DUSP22.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2635335
Product Specific Information
The antibody detects endogenous levels of total DUSP22 / JSP1 protein.
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586F2224; Dual specificity protein phosphatase 22; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK pathway associated phosphatase; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; Mitogen-activated protein kinase phosphatase x; PYST2
Gene Aliases: DUSP22; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
UniProt ID: (Human) Q9NRW4, (Mouse) Q99N11
Entrez Gene ID: (Human) 56940, (Mouse) 105352
negative regulation of transcription from RNA polymerase II promoter
negative regulation of T cell mediated immunity
protein dephosphorylation
transforming growth factor beta receptor signaling pathway
dephosphorylation
peptidyl-tyrosine dephosphorylation
regulation of cell proliferation
positive regulation of JNK cascade
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
inactivation of MAPK activity
apoptotic process
multicellular organism development
cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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