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Invitrogen
DUSP26 Polyclonal Antibody
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Product Details
PA5-114730
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DUSP26(Accession Q9BV47), corresponding to amino acid residues Q74-F124.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899366
Product Specific Information
Antibody detects endogenous levels of total DUSP26.
Target Information
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DSP-4; Dual specificity phosphatase SKRP3; Dual specificity protein phosphatase 26; dual-specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MGC1136; MGC2627; Mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase; Novel amplified gene in thyroid anaplastic cancer
Gene Aliases: 2310043K02Rik; DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; RGD1310090; SKRP3
UniProt ID: (Human) Q9BV47, (Mouse) Q9D700, (Rat) Q5FVI9
Entrez Gene ID: (Human) 78986, (Mouse) 66959, (Rat) 306527
negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
dephosphorylation
peptidyl-tyrosine dephosphorylation
negative regulation of protein kinase activity by regulation of protein phosphorylation
positive regulation of cell adhesion
negative regulation of ERK1 and ERK2 cascade
positive regulation of peptidyl-serine dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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