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OriGene
DUSP4 Monoclonal Antibody (OTI7C11), TrueMAB™
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FIGURE: 1 / 1
DUSP4 Antibody (TA809428) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DUSP4 (RC215252, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DUSP4. Positive lysates LY403296 (100 µg) and LC403296 (20 µg) can be purchased separately from OriGene.
Product Details
TA809428
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI7C11
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-257 of human DUSP4 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP-4; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP II; MKPII; serine/threonine specific protein phosphatase; VH1 homologous phosphatase 2
Gene Aliases: DUSP4; HVH2; MKP-2; MKP2; TYP; VH2
UniProt ID: (Human) Q13115
Entrez Gene ID: (Human) 1846
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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