Proteintech

DUSP7/PYST2 Polyclonal Antibody

DUSP7/PYST2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DUSP7/PYST2 Antibody (26910-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 26910-1-AP ( DUSP7/PYST2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

DUSP7/PYST2 Antibody in Western Blot (WB)

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Product Details

26910-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DUSP7/PYST2 Fusion Protein Ag25488 (60-102 aa encoded by BC104880)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IRSIIPNHA DKERFATRCK AATVLLYDEA TAEWQPEPGA PASV (60-102 aa encoded by BC104880)

Target Information

DUSP7 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory.

Addiction biology

Qiao X,Zhu Y,Dang W,Wang R,Sun M,Chen Y,Shi Y,Zhang L

Fri Jan 01 00:00:00 UTC 2021

Down-regulation of dual-specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2.

Genes to cells : devoted to molecular & cellular mechanisms

Kanda Y,Mizuno A,Takasaki T,Satoh R,Hagihara K,Masuko T,Endo Y,Tanabe G,Sugiura R

Mon Feb 01 00:00:00 UTC 2021

l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.

British journal of pharmacology

Leng YP,Ma YS,Li XG,Chen RF,Zeng PY,Li XH,Qiu CF,Li YP,Zhang Z,Chen AF

Sun Apr 01 00:00:00 UTC 2018

l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.

British journal of pharmacology

Leng YP,Ma YS,Li XG,Chen RF,Zeng PY,Li XH,Qiu CF,Li YP,Zhang Z,Chen AF

Sun Apr 01 00:00:00 UTC 2018

Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer.

Molecular cancer

Peng WX,Huang JG,Yang L,Gong AH,Mo YY

Tue Oct 17 00:00:00 UTC 2017

Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer.

Molecular cancer

Peng WX,Huang JG,Yang L,Gong AH,Mo YY

Tue Oct 17 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Dual specificity protein phosphatase 7; Dual specificity protein phosphatase MKP-X; Dual specificity protein phosphatase PYST2; dual-specificity phosphatase-7; MAP kinase phosphatase

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Gene Aliases: AU015694; DUSP7; mkp-X; MKPX; PYST2

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UniProt ID: (Human) Q16829, (Mouse) Q91Z46, (Rat) Q63340

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Entrez Gene ID: (Human) 1849, (Mouse) 235584, (Rat) 300980

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Function(s)

protein tyrosine phosphatase activity protein binding protein tyrosine/serine/threonine phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity phosphatase activity

Process(es)

inactivation of MAPK activity protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation negative regulation of MAP kinase activity MAPK cascade activation of MAPK activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DUSP7/PYST2 Polyclonal Antibody

DUSP7/PYST2 Antibody (26910-1-AP) in IHC (P)

Product Details

26910-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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