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Invitrogen
DUSP8 Polyclonal Antibody
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FIGURE: 1 / 1
DUSP8 Antibody (PA5-18007) in WB
Western blot analysis of DUSP8 using DUSP8 Polyclonal Antibody (Product # PA5-18007) (2 µg/mL) in staining of Human Cerebellum (A), Mouse (B), and Rat (C) Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Details
PA5-18007
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (AGDRLPRKVMDAK) corresponding to the N-terminus amino acids of DUSP8 (aa 2-14).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982531
Product Specific Information
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; OTTHUMP00000164487; serine/threonine specific protein phosphatase
Gene Aliases: 5530400B01Rik; AI593498; C11orf81; DUSP8; HB5; HVH-5; HVH8; M3/6; Nttp1; VH5
UniProt ID: (Human) Q13202, (Mouse) O09112
Entrez Gene ID: (Human) 1850, (Rat) 361679, (Mouse) 18218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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