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Product Details
12219-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DYNC1I2 Fusion Protein Ag2873 (330-638 aa encoded by BC015038)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HCQSAVMSA TFAKFHPNLV VGGTYSGQIV LWDNRSNKRT PVQRTPLSAA AHTHPVYCVN VVGTQNAHNL ISISTDGKIC SWSLDMLSHP QDSMELVHKQ SKAVAVTSMS FPVGDVNNFV VGSEEGSVYT ACRHGSKAGI SEMFEGHQGP ITGIHCHAAV GAVDFSHLFV TSSFDWTVKL WTTKNNKPLY SFEDNADYVY DVMWSPTHPA LFACVDGMGR LDLWNLNNDT EVPTASISVE GNPALNRVRW THSGREIAVG DSEGQIVIYD VGEQIAVPRN DEWARFGRTL AEINANRADA EEEAATRIPA (330-638 aa encoded by BC015038)
Target Information
Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex that transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins regulate Dynein activity, including Dynactin, LIS1 and nudel (nudE-like).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; cytoplasmic dynein intermediate chain 2 isoform 2.1; cytoplasmic dynein intermediate chain 2 isoform 2.2; cytoplasmic dynein intermediate chain 2 isoform 2.5; DH IC-2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic 1, intermediate chain 2; dynein, cytoplasmic, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; oncofetal protein (OFP); testis tissue sperm-binding protein Li 66n
Gene Aliases: 3110079H08Rik; AW554389; DIC74; DNCI2; DNCIC2; DYNC1I2; IC2
UniProt ID: (Human) Q13409, (Mouse) O88487
Entrez Gene ID: (Human) 1781, (Rat) 116659, (Mouse) 13427
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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