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DYNC2LI1 Polyclonal Antibody

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DYNC2LI1 Antibody (15949-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 15949-1-AP) (DYNC2LI1 antibody) at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

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Product Details

15949-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DYNC2LI1 Fusion Protein Ag8584 (1-352 aa encoded by BC006969)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPSETLWEI AKAEVEKRGI NGSEGDGAEI AEKFVFFIGS KNGGKTTIIL RCLDRDEPPK PTLALEYTYG RRAKGHNTPK DIAHFWELGG GTSLLDLISI PITGDTLRTF SLVLVLDLSK PNDLWPTMEN LLQATKSHVD KVIMKLGKTN AKAVSEMRQK IWNNMPKDHP QDHELIDPFP VPLVIIGSKY DVFQDFESEK RKVICKTLRF VAHYYGASLM FTSKSEALLL KIRGVINQLA FGIDKSKSIC VDQNKPLFIT AGLDSFGQIG SPPVPENDIG KLHAHSPMEL WKKVYEKLFP PKSINTLKDI KDPARDPQYA ENEVDEMRIQ KDLELEQYKR SSSKSWKQIE LDS (1-352 aa encoded by BC006969)

Target Information

DYNC2LI1 (dynein, cytoplasmic 2, light intermediate chain 1), also known as LIC3, D2LIC or CGI-60, is a 351 amino acid cytoplasmic protein belonging to the dynein light intermediate chain family. DYNC2LI1 may function as a motor for intraflagellar retrograde transport and in cilia biogenesis. The cytoplasmic dynein complex 2 may be composed of a DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains. DYNC2LI1 exists as five alternatively spliced isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia.

Human molecular genetics

King A,Hoch NC,McGregor NE,Sims NA,Smyth IM,Heierhorst J

Thu Aug 01 00:00:00 UTC 2019

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.

eLife

Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ

Tue Oct 16 00:00:00 UTC 2018

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.

eLife

Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ

Tue Oct 16 00:00:00 UTC 2018

Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.

Cilia

Duran I,Taylor SP,Zhang W,Martin J,Qureshi F,Jacques SM,Wallerstein R,Lachman RS,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Wed Sep 30 00:00:00 UTC 2020

Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.

Cilia

Duran I,Taylor SP,Zhang W,Martin J,Qureshi F,Jacques SM,Wallerstein R,Lachman RS,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Wed Sep 30 00:00:00 UTC 2020

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.

Scientific reports

Kessler K,Wunderlich I,Uebe S,Falk NS,Gießl A,Brandstätter JH,Popp B,Klinger P,Ekici AB,Sticht H,Dörr HG,Reis A,Roepman R,Seemanová E,Thiel CT

Wed Jul 01 00:00:00 UTC 2015

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.

Scientific reports

Kessler K,Wunderlich I,Uebe S,Falk NS,Gießl A,Brandstätter JH,Popp B,Klinger P,Ekici AB,Sticht H,Dörr HG,Reis A,Roepman R,Seemanová E,Thiel CT

Wed Jul 01 00:00:00 UTC 2015

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.

FEBS letters

Ichikawa M,Watanabe Y,Murayama T,Toyoshima YY

Thu Aug 04 00:00:00 UTC 2011

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.

FEBS letters

Ichikawa M,Watanabe Y,Murayama T,Toyoshima YY

Thu Aug 04 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Cytoplasmic dynein 2 light intermediate chain 1; Dynein 2 light intermediate chain; dynein, cytoplasmic 2, light intermediate chain 1; mD2LIC

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Gene Aliases: 4933404O11Rik; CGI-60; D2LIC; DYNC2LI1; LIC3; mD2LIC

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UniProt ID: (Human) Q8TCX1, (Mouse) Q8K0T2

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Entrez Gene ID: (Human) 51626, (Mouse) 213575

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Function(s)

motor activity protein binding dynein heavy chain binding molecular_function

Process(es)

multicellular organism development determination of left/right symmetry cell projection organization cilium assembly ER to Golgi vesicle-mediated transport antigen processing and presentation of exogenous peptide antigen via MHC class II

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DYNC2LI1 Polyclonal Antibody

DYNC2LI1 Antibody (15949-1-AP) in WB

Product Details

15949-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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