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Invitrogen
DYNLL1 Recombinant Rabbit Monoclonal Antibody (23GB5245)
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FIGURE: 1 / 3
DYNLL1 Antibody (MA5-53874) in WB
Western Blot analysis of DYNLL1. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DYNLL1 recombinant monoclonal antibody (Product # MA5-53874) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Product Details
MA5-53874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5245
Immunogen
A synthesized peptide derived from human DYNLL1 (1-48AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3248345
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8 kDa dynein light chain; 8kD LC; 8kDa LC; cytoplasmic dynein light polypeptide; DLC1DNCLC1; DLC8; DLC8MGC126137; DNCL1MGC126138; dynein LC8; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; dynein, cytoplasmic, light polypeptide 1; dynein, light chain, LC8-type 1; H LC8; LC8-type 1; MGC126137; MGC126138; mPIN; PIN; PINLC8a; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase
Gene Aliases: 8kDLC; DLC1; DLC8; DNCL1; DNCLC1; DYNLL1; HDLC1; LC8; LC8a; PIN
UniProt ID: (Human) P63167, (Rat) P63170, (Mouse) P63168
Entrez Gene ID: (Human) 8655, (Rat) 58945, (Mouse) 56455
transcription, DNA-templated
regulation of transcription, DNA-templated
nitric oxide biosynthetic process
transport
apoptotic process
microtubule-based process
substantia nigra development
neurotransmitter metabolic process
negative regulation of phosphorylation
negative regulation of catalytic activity
regulation of catalytic activity
G2/M transition of mitotic cell cycle
ER to Golgi vesicle-mediated transport
female gamete generation
anatomical structure morphogenesis
viral process
macroautophagy
antigen processing and presentation of exogenous peptide antigen via MHC class II
actin cytoskeleton organization
intraciliary retrograde transport
cilium morphogenesis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
microtubule-based movement
negative regulation of nitric oxide biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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