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Rockland
Dab1 Polyclonal Antibody
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Product Details
100-401-225
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide corresponding to the C-terminal region of murine Dab1 at amino acids 400-555.
Conjugate
Form
Liquid
Concentration
75 mg/mL
Storage buffer
0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is directed against Dab1 from mouse. Cross-reactivity with other species has not been determined. No reaction occurs with human or mouse Dab2.
Target Information
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Disabled homolog 1; mDab1; RP23-356E21.1; yotari
Gene Aliases: AI956902; C630028C02Rik; Dab1; scm; scr; scrambler; yot
UniProt ID: (Mouse) P97318
Entrez Gene ID: (Mouse) 13131
neuron migration
negative regulation of cell adhesion
small GTPase mediated signal transduction
multicellular organism development
nervous system development
central nervous system development
adult walking behavior
dendrite development
cerebellum structural organization
cerebral cortex cell migration
cerebral cortex radially oriented cell migration
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
radial glia guided migration of Purkinje cell
cell differentiation
intracellular signal transduction
positive regulation of neuron differentiation
positive regulation of protein kinase activity
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
lateral motor column neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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