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Product Details
PA5-47305
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse DcTRAIL R1/TNFRSF23 Met30-Ser156
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2605562
Product Specific Information
In Western blots, approximately 30% cross-reactivity with recombinant mouse (rm) DcTRAIL R2 is observed and less than 1% cross-reactivity with rmTRAIL R2, recombinant human (rh) TRAIL R3, and rhTRAIL R4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help faciliate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Decoy TRAIL receptor 1; MGC123882; MGC123883; TNF receptor family member SOB; TNF receptor homolog 1; Tumor necrosis factor receptor p60 homolog 1; Tumor necrosis factor receptor superfamily member 23
Gene Aliases: Dctrailr1; mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1; Tnfrsf23; TNFRSFH23
UniProt ID: (Mouse) Q9ER63
Entrez Gene ID: (Mouse) 79201
Performance Guarantee
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