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Invitrogen
Decorin Polyclonal Antibody
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Product Details
PA5-85132
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Decorin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792279
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (81%), Dog (92%), Pig (92%), Rabbit (90%), Chicken (80%), Sheep (91%), Chimpanzee (100%), Bovine (91%), Guinea pig (92%).
Positive Control: RD.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bone proteoglycan II; Decorin; dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B
Gene Aliases: CSCD; DCN; DSPG2; PG40; PGII; PGS2; SLRR1B
UniProt ID: (Human) P07585
Entrez Gene ID: (Human) 1634
kidney development
placenta development
negative regulation of protein kinase activity
skeletal muscle tissue development
aging
response to mechanical stimulus
organ morphogenesis
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of macroautophagy
negative regulation of angiogenesis
cytokine-mediated signaling pathway
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
response to lipopolysaccharide
wound healing
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
negative regulation of vascular endothelial growth factor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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