Proteintech

Dematin Polyclonal Antibody

View all (8) Dematin antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (2)

Dematin Antibody in Western Blot (WB)

Dematin Antibody in Western Blot (WB)

FIGURE: 1 / 2

Dematin Antibody (16808-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 16808-1-AP) (Dematin antibody) at dilution of 1:5,000 incubated at room temperature for 1.5 hours.

Dematin Antibody in Western Blot (WB)

Dematin Antibody in Western Blot (WB)

Product Image Gallery

Dematin Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 16808-1-AP) (Dematin antibody) at dilution of 1:5,000 incubated at room temperature for 1.5 hours.

Dematin Antibody in Western Blot (WB) — Rat brain tissue were subjected to SDS PAGE followed by western blot with 16808-1-AP ( Dematin antibody at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

16808-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Dematin Fusion Protein Ag10300 (1-405 aa encoded by BC017445)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MERLQKQPL TSPGSVSPSR DSSVPGSPSS IVAKMDNQVL GYKDLAAIPK DKAILDIERP DLMIYEPHFT YSLLEHVELP RSRERSLSPK STSPPPSPEV WADSRSPGII SQASAPRTTG TPRTSLPHFH HPETSRPDSN IYKKPPIYKQ RESVGGSPQT KHLIEDLIIE SSKFPAAQPP DPNQPAKIET DYWPCPPSLA VVETEWRKRK ASRRGAEEEE EEEDDDSGEE MKALRERQRE ELSKVTSNLG KMILKEEMEK SLPIRRKTRS LPDRTPFHTS LHQGTSKSSS LPAYGRTTLS RLQSTEFSPS GSETGSPGLQ NGEGQRGRMD RGNSLPCVLE QKIYPYEMLV VTNKGRTKLP PGVDRMRLER HLSAEDFSRV FAMSPEEFGK LALWKRNELK KKASLF (1-405 aa encoded by B C017445)

Target Information

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader-Willi syndrome.

Frontiers of medicine

Yang Y,Li G,Wang Y,Sun Y,Xu C,Wei Z,Zhang S,Gao L,Liu S,Zhao J

Thu Dec 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9

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Gene Aliases: AI325486; dematin; DMT; DMTN; Epb4.9; EPB49

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UniProt ID: (Human) Q08495, (Mouse) Q9WV69

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Entrez Gene ID: (Human) 2039, (Rat) 361069, (Mouse) 13829

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actin binding receptor binding protein binding spectrin binding protein self-association

protein complex assembly cytoskeleton organization regulation of cell shape regulation of lamellipodium assembly positive regulation of fibroblast migration negative regulation of peptidyl-threonine phosphorylation negative regulation of cell-substrate adhesion actin cytoskeleton organization positive regulation of blood coagulation regulation of actin cytoskeleton organization negative regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source calcium-mediated signaling using extracellular calcium source erythrocyte development negative regulation of peptidyl-tyrosine phosphorylation actin filament bundle assembly regulation of filopodium assembly actin filament capping negative regulation of focal adhesion assembly transmembrane transport protein secretion by platelet cellular response to calcium ion cellular response to cAMP positive regulation of wound healing negative regulation of protein targeting to membrane actin filament reorganization negative regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation positive regulation of integrin-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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