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Bethyl Laboratories
Derlin-1 Polyclonal Antibody
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Derlin-1 Antibody (A302-849A) in IHC (P)
Detection of human Derlin-1 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Derlin-1 (Product # A302-849A) (Lot 1) used at a dilution of 1:200 (1 µg/mL). Detection: Vector Laboratories ImmPACT NovaRED Peroxidase Substrate.
Product Details
A302-849A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 201 and 251 of human Der1-like Domain Family Member 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Bovine and Orangutan
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; Derlin-1; DERtrin-1
Gene Aliases: 1110021N07Rik; AI195141; AW551338; DER-1; DER1; DERL1; Derlin-1; UNQ243/PRO276
UniProt ID: (Human) Q9BUN8, (Mouse) Q99J56
Entrez Gene ID: (Human) 79139, (Mouse) 67819
transport
response to unfolded protein
protein transport
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
positive regulation of protein ubiquitination
protein destabilization
positive regulation of protein binding
cellular response to unfolded protein
protein homooligomerization
ER-associated misfolded protein catabolic process
intracellular transport of viral protein in host cell
ERAD pathway
establishment of protein localization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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